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Selling retatrutide on TikTok or Telegram is illegal in the UK, as it is an unlicensed drug that cannot be marketed or supplied for human use under the Human Medicines Regulations 2012

GLP-1 therapy may help by reducing the biological drive to overeat

Health Canada has approved six medications specifically for chronic weight management: orlistat (Xenical), liraglutide (Saxenda), naltrexone-bupropion (Contrave), semaglutide (Wegovy), tirzepatide (Zepbound), and setmelanotide (Imcivree, for rare genetic forms of obesity only)

One important caveat: IGF-1 LR3 retains its ability to bind the insulin receptor (IR), forming hybrid IGF1R/IR complexes